The alcoholic extract of seeds and leaves of Achyranthes aspera L. (Amaranthaceae) was studied for hepatoprotective activity. The rats fed only on alcohol produced significant increase in the levels of enzyme markers of tissue damage viz. Alanine amino transferase (ALT), Aspartate amino transferase (AST) and alkaline phosphatase (ALP). Antioxidant activity was studied by estimation of thiobarbituric acid reactive substance (TBARS), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GTH). The activity was compared to the standard control Silymarin fed rats. Reversal of hepatic steatosis was observed both biochemically and histologically. Treatment with 250 mg/kg body weight of the extracts significantly reduced the levels of the enzyme markers which indicate hepatic tissue damage and oxidation of the cells.
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